Replication timing of control and siRNA PR-set7 cells

ABSTRACT: Although histone modifications have been implicated in many DNA-dependent processes, their precise role in DNA replication remains poorly understood. Here, we show that the regulation of histone H4-K20 methylation states, in particular for the monomethylation, is a critical determinant of licensing and time activation of replication origins in mammalian cells. Two experimental condition : shRNA LUC cells (control) versus siRNA Prset-7 cells

ORGANISM(S): Homo sapiens

SUBMITTER: Jean-Charles Cadoret 

PROVIDER: E-GEOD-69083 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress