Genome expression profiling identifies host-directed antimicrobial drugs against respiratory infection by nontypable Haemophilus influenzae

ABSTRACT: Objectives: Therapies being safe, effective and not vulnerable to develop resistance are highly desirable to counteract bacterial infections. Host-directed therapeutics is an alternative to conventional antibiotics based on perturbing host pathways subverted by pathogens during their life cycle by the use of host-directed drugs to counteract microbial infections. This study sought to identify cellular genes and pathways differentially expressed during airways epithelial infection by nontypable Haemophilus influenzae (NTHi). NTHi is an opportunistic pathogen that is an important cause of exacerbation of chronic obstructive pulmonary disease (COPD). Based on the proposed relationship between NTHi intracellular location and persistence, the antimicrobial potential of a panel of drugs perturbi

ORGANISM(S): Homo sapiens

SUBMITTER: Junkal Garmendia 

PROVIDER: E-GEOD-69134 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress