Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Anneleen Decock
PROVIDER: E-GEOD-69268 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Decock Anneleen A Ongenaert Maté M Cannoodt Robrecht R Verniers Kimberly K De Wilde Bram B Laureys Geneviève G Van Roy Nadine N Berbegall Ana P AP Bienertova-Vasku Julie J Bown Nick N Clément Nathalie N Combaret Valérie V Haber Michelle M Hoyoux Claire C Murray Jayne J Noguera Rosa R Pierron Gaelle G Schleiermacher Gudrun G Schulte Johannes H JH Stallings Ray L RL Tweddle Deborah A DA De Preter Katleen K Speleman Frank F Vandesompele Jo J
Oncotarget 20160101 2
Accurate assessment of neuroblastoma outcome prediction remains challenging. Therefore, this study aims at establishing novel prognostic tumor DNA methylation biomarkers. In total, 396 low- and high-risk primary tumors were analyzed, of which 87 were profiled using methyl-CpG-binding domain (MBD) sequencing for differential methylation analysis between prognostic patient groups. Subsequently, methylation-specific PCR (MSP) assays were developed for 78 top-ranking differentially methylated region ...[more]