Transcription profiling of Drosophila ovaries from bam mutant and stwl bam double mutant females

ABSTRACT: Abstract: During Drosophila oogenesis, germline stem cell (GSC) identity is maintained largely by preventing the expression of factors that promote differentiation. This is accomplished via the activity of several genes acting either in the GSC or its niche. The translational repressors, Nanos and Pumilio, act in GSCs to prevent differentiation, likely by inhibiting translation of early differentiation factors, while niche signals prevent differentiation by silencing transcription of the differentiation factor Bam. We have found that the DNA-associated protein Stonewall (Stwl) is also required for GSC maintenance. stwl is required cell-autonomously; clones of stwl- germ cells were lost by differentiation, and ectopic Stwl caused an expansion of GSCs. stwl mutants acted as Suppressors of Va

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Dennis McKearin 

PROVIDER: E-GEOD-6928 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress