Transcription profiling of rat cirrhotic liver treated with angiogenesis inhibitors

ABSTRACT: Background and aims: There are considerable evidences demonstrating that angiogenesis and chronic inflammation are mutually dependent. However, although cirrhosis progression is characterized with a chronic hepatic inflammatory process, this connection is not sufficiently explored as a therapeutic strategy. Therefore, this study was aimed to assess the potential benefits of targeting angiogenesis in cirrhotic livers to modulate inflammation and fibrosis. For this purpose, we evaluate the therapeutic utility of angiogenesis inhibitors. Methods: The in vivo effects of angiogenesis inhibitors were monitored in liver of cirrhotic rats by measuring angiogenesis, inflammatory infiltrate, fibrosis, a-smooth muscle actin (a-SMA) accumulation, differential gene expression (by microarrays), and port

ORGANISM(S): Rattus norvegicus

SUBMITTER: Manuel Morales-Ruiz 

PROVIDER: E-GEOD-6929 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress