A Blood Transcriptional Diagnostic Assay for Septicemic Melioidosis

ABSTRACT: Melioidosis, caused by Gram negative bacteria Burkholderia pseudomallei, is a major type of community-acquired septicemia in Southeast Asia and Northern Australia with high mortality and morbidity rate. More accurate and rapid diagnosis is needed for improving the management of septicemic melioidosis. We previously identified 37-gene candidate signature to distinguish septicemic melioidosis from sepsis due to other pathogens. The aims of this current study were to independently validate our previous biomarker and consolidate gene selection from each of our microarray data set for establishing a targeted assay for the differential diagnosis of melioidosis. Blood samples were collected from patients who presented with severe inflammatory response syndromes from 3 provincial hospitals in Nort

ORGANISM(S): Homo sapiens

SUBMITTER: Scott Presnell 

PROVIDER: E-GEOD-69528 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress