Transcription profiling of human prostate cancer between african-american and european-american men

ABSTRACT: The incidence and mortality rates of prostate cancer are significantly higher in African-American men when compared to European-American men. We tested the hypothesis that differences in tumor biology contribute to this survival health disparity. Using microarray technology, we obtained gene expression profiles of primary prostate tumors resected from 33 African-American and 36 European-American patients. These tumors were matched on clinical parameters. We also evaluated 18 non-tumor prostate tissues from 7 African-American and 11 European-American patients. The resulting datasets were analyzed for expression differences on the gene and pathway level comparing African-American with European-American patients. Our analysis revealed a significant number of genes, e.g., 162 transcripts at a

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Scott Hudson 

PROVIDER: E-GEOD-6956 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress