Transcription profiling of mouse bipotential embryonic liver cells to identify liver progenitor cell surface markers (430)

ABSTRACT: The ability to purify to homogeneity a population of hepatic progenitor cells from adult liver is critical for their characterization prior to any therapeutic application. As a step in this direction, we have utilized gene profiling of a bipotential liver cell line from dpc 14 mouse embryonic liver to catalog genes expressed by liver progenitor cells. These cells, known as Bipotential Mouse Embryonic Liver (BMEL) cells, proliferate in an undifferentiated state and are capable of differentiating into hepatocyte-like and cholangiocyte-like cells in vitro. Upon transplantation, BMEL cells are capable of differentiating into hepatocytes and cholangiocytes in vivo. Microarray analysis of gene expression in the 9A1 and 14B3 BMEL cell lines grown under proliferating and differentiating condit

ORGANISM(S): Mus musculus

SUBMITTER: Scott Andrew Ochsner 

PROVIDER: E-GEOD-6957 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress