Refining brucellosis diagnosis by blood transcriptional profiling

ABSTRACT: Diagnosis of brucellosis remains challenging for several reasons, including lack of culture sensitivity, nonspecific symptomatology, and high prevalence of positive serology in endemic areas. The main objectives of this study were to identify blood biomarkers specific to brucellosis compared to other endemic infections and to monitor changes in blood biomarkers during treatment. To obtain a global profile of the disease, we employed RNA sequencing (RNAseq) of whole blood RNA to measure host response against brucellosis infection in patients from Macedonia and Spain. Long-term follow up of patients was used to classify patients as having acute or chronic/reinfection brucellosis and as treatment responders and non-responders. We observed distinct gene expression differences between samples f

ORGANISM(S): Homo sapiens

SUBMITTER: Scott Presnell 

PROVIDER: E-GEOD-69597 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress