Splenic gene expression profile of mice immunized with an anti-Fasciola hepatica vaccine candidate: insights into the immunological mechanisms leading to protection

ABSTRACT: Fasciolosis remains an important food-borne tremaode disease causing high morbidity around the world and affecting grazing animals and humans. A deeper understanding concerning the molecular mechanisms by which Fasciola hepatica infection occurs as well as the molecular basis involved in acquiring protection is extremely important in designing and selecting new vaccine candidates. The present study gives a first report of microarray-based technology for describing changes in splenic gene expression profile for mice immunised with a highly effective, protection-inducing,multi-epitope, subunit-based, chemically-synthesised vaccine candidate. Female CD1 mice were immunised with synthetic peptides containing B- and T-cell epitopes as novel vaccine candidates and challenged with Fasciola hepati

ORGANISM(S): Mus musculus

SUBMITTER: Jose Rojas-Caraballo 

PROVIDER: E-GEOD-69611 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress