Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

ABSTRACT: Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors. Inhibition of Wnt secretion by blocking an essential post-translational modification, palmitoleation, provides a useful therapeutic intervention. Inhibition of PORCN in RSPO3-translocated cancers via treatment with ETC-159 causes a marked remodeling of the transcriptome, with loss of cell cycle, stem cell, and proliferation genes and an increase in differentiation markers. Inhibition of Wnt signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers. RNA-seq of colorectal PDXs with confirmed R-spondin fusion genes. RNA-seq was performed in 2 conditions (Vehicle and treatment with ETC-159 (an inhibitor of PORCN) with 4 replicates per condition.

ORGANISM(S): Homo sapiens

SUBMITTER: NATHAN HARMSTON 

PROVIDER: E-GEOD-69687 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors. Whether these mutations identify a clinical opportunity is an important question. Inhibition of Wnt secretion by blocking an essential post-translational modification, palmitoleation, provides a useful therapeutic intervention. We developed a novel potent, orally available PORCN inhibitor, ETC-1922159 (henceforth called ETC-159) that blocks the se  ...[more]

Similar Datasets

Transcriptomics Wnt addiction of genetically defined cancers reversed by PORCN inhibition
2015-08-12 | GSE69687 | GEO
Transcriptomics Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts
2014-04-19 | E-GEOD-56911 | biostudies-arrayexpress
Transcriptomics Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts
2014-04-19 | GSE56911 | GEO
Transcriptomics Transcriptional response to PORCN inhibition using an in vitro model of RNF43 mutant pancreatic adenocarcinoma (HPAF-II)
2018-12-04 | GSE118190 | GEO
Transcriptomics Transcriptional response to PORCN inhibition using an orthotopic model of RNF43 mutant pancreatic adenocarcinoma (HPAF-II)
2018-12-04 | GSE118041 | GEO
Transcriptomics Transcriptional response to PORCN inhibition using a subcutaneous model of RNF43 mutant pancreatic adenocarcinoma (HPAF-II)
2018-12-04 | GSE118179 | GEO
Transcriptomics Gene expression data of organoids derived from human gastric tumor and normal stomach samples.
2018-08-14 | GSE112369 | GEO
Transcriptomics Gastric Myofibroblasts Control Chief Cell differentiation, and their recovery from SPEM
2022-01-01 | GSE145087 | GEO
Transcriptomics An unorthodox AR addiction drives enzalutamide resistance in prostate cancer (RNA-Seq)
2020-08-20 | GSE136129 | GEO
Genomics An unorthodox AR addiction drives enzalutamide resistance in prostate cancer (ChIP-Seq)
2020-08-20 | GSE136128 | GEO