Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping

ABSTRACT: The identity and developmental potential of a human cell is specified by its epigenome that is largely defined by patterns of chromatin modifications including histone acetylation. Here we report high-resolution genome-wide mapping of diacetylation of histone H3 at Lys 9 and Lys 14 in resting and activated human T cells by genome-wide mapping technique (GMAT). Our data show that high levels of the H3 acetylation are detected in gene-rich regions. The chromatin accessibility and gene expression of a genetic domain is correlated with hyperacetylation of promoters and other regulatory elements but not with generally elevated acetylation of the entire domain. Islands of acetylation are identified in the intergenic and transcribed regions. The locations of the 46,813 acetylation islands identif

ORGANISM(S): Homo sapiens

SUBMITTER: Keji Zhao 

PROVIDER: E-GEOD-6974 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress