Storage time does not modify the gene expression profile of cryopreserved human metaphase II oocytes

ABSTRACT: Study question: Does storage time impact on transcriptome of slowly frozen cryopreserved human metaphase II (MII) oocytes? Summary answer: For the first time, we demonstrate that the length of cryostorage has no effect on the gene expression profile of human metaphase II oocytes. What is known already: Oocyte cryopreservation is a largely-used technique in IVF for storage of surplus oocytes, as well as for fertility preservation (i.e., women undergoing gonadotoxic therapies) and oocyte donation programs. Although it is known that cryopreservation negatively impacts on oocyte physiology and it is associated with decrease of transcripts, no experimental data about the effect of storage time on the oocyte molecular profile are available to date. Study design, size, duration: This study inclu

ORGANISM(S): Homo sapiens

SUBMITTER: Sara Stigliani 

PROVIDER: E-GEOD-69768 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress