MeDIP and hMeDIP assays using human placentas of obese and lean (healthy weight) pregnancies

ABSTRACT: Maternal obesity has both a direct effect on the outcome of pregnancy but also programs the fetus for obesity and metabolic syndrome in later life. Due to its roles at the interface between mother and fetus, the placenta transduces and mediates the effects of the obese intrauterine environment on the fetus. Here we have generated genome-scale high-resolution maps of 5mC and 5hmC in human placentas of obese and healthy weight pregnancies. Widespread alterations to the placental epigenome identified across the genome in the setting of maternal adiposity are primarily characterized by increase in 5mC and reciprocal decrease in 5hmC. This is also evident at the two pregnancy-associated gene clusters on chromosomes 17 and 19. In addition, maternal adiposity is associated with downregulation of

ORGANISM(S): Homo sapiens

SUBMITTER: Kohzoh Mitsuya 

PROVIDER: E-GEOD-69769 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress