Critical role of histone turnover in neuronal transcription and plasticity [ChIP-seq]

ABSTRACT: Turnover and exchange of nucleosomal histones and their variants, a process long believed to be static in post-replicative cells, remains largely unexplored in brain. Here, we describe a novel mechanistic role for HIRA (histone cell cycle regulator) and proteasomal degradation associated histone dynamics in the regulation of activity-dependent transcription, synaptic connectivity and behavior. We uncover a dramatic developmental profile of nucleosome occupancy across the lifespan of both rodents and humans, with the histone variant H3.3 accumulating to near saturating levels throughout the neuronal genome by mid-adolescence. Despite such accumulation, H3.3 containing nucleosomes remain highly dynamic–in a modification independent manner–to control neuronal- and glial- specific gene express

ORGANISM(S): Mus musculus

SUBMITTER: Li Shen 

PROVIDER: E-GEOD-69806 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress