Genome-wide screen reveals rhythmic regulation of genes involved in odor processing in the olfactory epithelium

ABSTRACT: Odor discrimination behavior displays circadian fluctuations in mice indicating that mammalian olfactory function is under control of the circadian system. This is further supported by the facts that odor discrimination rhythms depend on the presence of clock genes and that olfactory tissues contain autonomous circadian clocks. However, the molecular link between circadian function and olfactory processing is still unknown. In order to elucidate the molecular mechanisms underlying this link, we focused on the olfactory epithelium (OE), the primary target of odors and the site of the initial events in olfactory processing. We asked whether olfactory sensory neurons (OSNs) within the OE possess an autonomous circadian clock and whether olfactory pathways are under circadian control. Employin

ORGANISM(S): Mus musculus

SUBMITTER: Karsten Jürchott 

PROVIDER: E-GEOD-69853 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress