The Epigenomic Landscape of Prokaryotes

ABSTRACT: DNA methylation is an important regulator of genome function in the eukaryotes, but it is currently unclear if the same is true in prokaryotes. While regulatory functions have been demonstrated for a small number of bacteria, there have been no large-scale studies of prokaryotic methylomes and the full repertoire of targets and biological functions of DNA methylation remains unclear. Here we applied single-molecule, real-time sequencing to directly study the methylomes of 232 phylogenetically diverse prokaryotes. Collectively, we identified 834 methylated motifs, enabling the specific annotation of 415 DNA methyltransferases (MTases), and adding substantially to existing databases of MTase specificities. While the majority of MTases function as components of restriction-modification syste

ORGANISM(S): Flexibacter litoralis DSM 6794

SUBMITTER: Matthew Blow 

PROVIDER: E-GEOD-69872 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress