MicroRNAs of the RPE are essential for RPE differentiation and photoreceptor maturation (mRNA)

ABSTRACT: Dysfunction of the retinal pigmented epithelium (RPE) results in degeneration of photoreceptors and vision loss and is correlated with common blinding disorders in humans. Although many protein-coding genes are known to be expressed in RPEs and important for their development and maintenance, virtually nothing is known about the in vivo roles of non-protein coding transcripts in RPEs. The expression patterns of microRNAs (miRNAs) have been analyzed in a variety of ocular tissues, and few were implicated to play role in RPE based on studies in cell lines. Herein, through RPE specific conditional mutagenesis of Dicer1 or DGCR8, the importance of miRNA for RPE differentiation was uncovered. Interestingly, miRNAs were found to be dispensable for maintaining the RPE fate and survival, and yet t

ORGANISM(S): Mus musculus

SUBMITTER: Metsada Pasmanik-Chor 

PROVIDER: E-GEOD-69881 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress