Mapping of variable DNA methylation across multiple cell types defines a dynamic regulatory landscape of the human genome

ABSTRACT: DNA methylation is an important epigenetic modification involved in many biological processes and diseases. Many studies have mapped DNA methylation changes associated with embryogenesis, cell differentiation and cancer at a genome-wide scale. Our understanding of genome-wide DNA methylation changes in a developmental or disease-related context has been steadily growing. However, the investigation of which CpGs are variably methylated in different normal cell or tissue types is still limited. Here we present an in-depth analysis of 54 single-CpG-resolution DNA methylomes of normal human cell types by integrating high-throughput sequencing-based methylation data. We find that the percentage of unmethylated CpGs is relatively fixed regardless of cell type. However, which CpGs are unmethylate

ORGANISM(S): Homo sapiens

SUBMITTER: Daofeng Li 

PROVIDER: E-GEOD-69894 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress