MicroRNAs defining side population of human malignant mesothelioma cell lines identified by microarray analysis

ABSTRACT: Intratumoral heterogeneity is a major barrier against effective cancer therapy. Human malignant mesothelioma (HMM) that is closely associated with asbestos exposure is extremely heterogeneous in morphology and molecular phenotype. Contrast to genetic mutations, the role of epigenetic modifications in the generation and maintenance of heterogeneous populations in cancers remains largely undetermined. The present study was performed to investigate underlying molecular mechanisms for the emergence of intratumoral heterogeneity by identifying the global microRNA expression profile of distinct subpopulations of MS1 cell line, a HMM cell line. More aggressive cancer cells could be enriched by side population (SP) assay in HMM [20]. The sorted SP and NSP subpopulations were subjected to the micro

ORGANISM(S): Homo sapiens

SUBMITTER: Myung-Chul Kim 

PROVIDER: E-GEOD-69910 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress