Systematic analysis of time resolved transcriptional signature of the cross-talk between HGF and IL-6 refines the role of Cxcl10 in hepatocyte proliferation control

ABSTRACT: Liver regeneration is characterized by a scheduled sequence of inner and intra-cellular signaling events. It starts with an initial inflammatory phase, followed by a period of rapidly proliferating hepatocytes and stopping abruptly when the liver mass is restored. The cytokines hepatocellular growth factor (HGF) and interleukin 6 (IL-6) play a pivotal role during this process with the former driving proliferation that is enhanced by the latter. While the individual importance of HGF and IL6 has been studied comprahensively the role of cross-talk in control of hepatic proliferation is jet largely unknown. To this end, we performed time-resolved transcriptional profiling of of murine hepatocytes stimulated with HGF and IL-6 indiviually as well as in combination. Thorough systematic investiga

ORGANISM(S): Mus musculus

SUBMITTER: Hauke Busch 

PROVIDER: E-GEOD-69928 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress