Transcription profiling time series of the response of Rattus norvegicus nasal epithelial cells to treatment with various doses of formaldehyde

ABSTRACT: Formaldehyde, an important industrial chemical, is used for multiple commercial purposes throughout the industrialized world. This simple, one carbon aldehyde is a natural metabolite formed in cells throughput the body. However, it is also a rodent nasal carcinogen, when inhaled by rats every day for two-years at irritant concentrations. High tumor incidences occur at concentration of 10 ppm and above; no tumors are observed at concentrations below 6.0 ppm. The US Environmental Protection Agency (US EPA) is now (2007) conducting a risk assessment to try to evaluate possible cancer risks for much lower levels of human exposure. Sensitive methods are needed to evaluate tissue responses below those concentrations that are clearly irritant or carcinogenic. This microarray study was under

ORGANISM(S): Rattus norvegicus

SUBMITTER: Russell Scott Thomas 

PROVIDER: E-GEOD-7002 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress