Negative Regulation of Filamentous Growth in Candida albicans by Dig1p

ABSTRACT: Candida albicans is an opportunistic fungal pathogen capable of causing superficial and systemic infections in humans. The ability of C. albicans to switch between various morphological forms depending on its host environment is thought to contribute to its virulence. Filamentous growth states are associated with tissue invasion, biofilm formation, evasion of innate host defences and mating. Although the mechanisms of activation of filamentous growth pathways are well understood, less is known about which factors control the negative regulation of filamentation. In this study, we have identified a previously uncharacterized Orf that shares sequence similarity with Saccharomyces cerevisiae Dig1p and Dig2p. Deletion of the gene encoding this Orf triggers invasive growth in C. albicans and so

ORGANISM(S): Candida albicans

SUBMITTER: Hannah Regan 

PROVIDER: E-GEOD-70085 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress