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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from DM1, DM2 and Normal Adult Skeletal Muscle Biopsies

ABSTRACT: DM1 and DM2 biopsies from patients were compared to Normal adult individuals Keywords: 3 groups of samples 10 DM1 biopsies, 20 DM2 biopsies, and 6 Normal individuals biopsies

ORGANISM(S): Homo sapiens

SUBMITTER: Mario Sirito

PROVIDER: E-GEOD-7014 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differences in aberrant expression and splicing of sarcomeric proteins in the myotonic dystrophies DM1 and DM2.

Vihola Anna A Bachinski Linda L LL Sirito Mario M Olufemi Shodimu-Emmanuel SE Hajibashi Shohrae S Baggerly Keith A KA Raheem Olayinka O Haapasalo Hannu H Suominen Tiina T Holmlund-Hampf Jeanette J Paetau Anders A Cardani Rosanna R Meola Giovanni G Kalimo Hannu H Edström Lars L Krahe Ralf R Udd Bjarne B

Acta neuropathologica 20100112 4

Aberrant transcription and mRNA processing of multiple genes due to RNA-mediated toxic gain-of-function has been suggested to cause the complex phenotype in myotonic dystrophies type 1 and 2 (DM1 and DM2). However, the molecular basis of muscle weakness and wasting and the different pattern of muscle involvement in DM1 and DM2 are not well understood. We have analyzed the mRNA expression of genes encoding muscle-specific proteins and transcription factors by microarray profiling and studied sele ...[more]

PMID: 20066428

Publication: 1/2

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