Identification of novel biomarkers and potential target molecules of human hepatocellular carcinoma using THOC5, a member of the transcription/export (TREX) complex, depleted system

ABSTRACT: Hepatocellular carcinoma (HCC) is a frequent cancer with poor prognosis and with limited possibilities for anti-cancer treatment. Evidence has recently accumulated suggesting that multiple signaling pathways are activated in human cancer. It has been recently shown by exosome sequencing of HCC that 161 putative driver genes are associated with 11 recurrently altered pathways, suggesting that we need to inhibit these multiple pathways for HCC therapy. THOC5, a member of transcription/export (TREX) complex, that plays a role in less than 1% of mRNA processing in normal cells such as fibroblasts or macrophages, is not required for maintenance of mature hepatocytes. In this study, we have examined the role of THOC5 in human HCC. Enhanced THOC5 expression was not observed in differentiatio

ORGANISM(S): Homo sapiens

SUBMITTER: Doan Duy Hai Tran 

PROVIDER: E-GEOD-70178 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress