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Transcription profiling of mouse dendritic cells from Flt3+CD11b+ progenitors in vitro

ABSTRACT: Assessing the gene expression repertoire of antigen presenting dendritic cells

ORGANISM(S): Mus musculus

SUBMITTER: Thomas Hieronymus

PROVIDER: E-GEOD-702 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Progressive and controlled development of mouse dendritic cells from Flt3+CD11b+ progenitors in vitro.

Hieronymus Thomas T Gust Tatjana C TC Kirsch Ralf D RD Jorgas Thorsten T Blendinger Gitta G Goncharenko Mykola M Supplitt Kamilla K Rose-John Stefan S Müller Albrecht M AM Zenke Martin M

Journal of immunology (Baltimore, Md. : 1950) 20050301 5

Dendritic cells (DC) represent key regulators of the immune system, yet their development from hemopoietic precursors is poorly defined. In this study, we describe an in vitro system for amplification of a Flt3(+)CD11b(+) progenitor from mouse bone marrow with specific cytokines. Such progenitor cells develop into both CD11b(+) and CD11b(-) DC, and CD8alpha(+) and CD8alpha(-) DC in vivo. Furthermore, with GM-CSF, these progenitors synchronously differentiated into fully functional DC in vitro. T ...[more]

PMID: 15728461

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