Differential gene expression to VEGF in aorta from wild-type and C42S PKARI knock-in mice

ABSTRACT: Angiogenesis is essential for tissue development, wound healing and tissue perfusion, with its dysregulation linked-to tumorigenesis, rheumatoid arthritis and heart disease. Here we show pro-angiogenic stimuli couple to NADPH oxidase-dependent generation of oxidants that catalyse an activating intermolecular-disulphide between regulatory-RI? subunits of protein kinase A (PKA), which stimulates PKA-dependent ERK signalling. This is crucial to blood vessel growth as 'redox-dead' Cys17Ser RI? knock-in mice fully resistant to PKA disulphide-activation have deficient angiogenesis in models of hind limb ischaemia and tumour-implant growth. Disulphide-activation of PKA represents a new therapeutic target in diseases with aberrant angiogenesis. The aim of this study was to identify unique differen

ORGANISM(S): Mus musculus

SUBMITTER: Matthew Arno 

PROVIDER: E-GEOD-70216 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress