The impact of P53 loss on transcriptome changes following loss of Apc in the intestine

ABSTRACT: BACKGROUND: p53 is an important tumor suppressor with a known role in the later stages of colorectal cancer, but its relevance to the early stages of neoplastic initiation remains somewhat unclear. Although p53-dependent regulation of Wnt signalling activity is known to occur, the importance of these regulatory mechanisms during the early stages of intestinal neoplasia has not been demonstrated. METHODS: We have conditionally deleted the Adenomatous Polyposis coli gene (Apc) from the adult murine intestine in wild type and p53 deficient environments and subsequently compared the phenotype and transcriptome profiles in both genotypes. RESULTS: Expression of p53 was shown to be elevated following the conditional deletion of Apc in the adult small intestine. Furthermore, p53 status was shown

ORGANISM(S): Mus musculus

SUBMITTER: Karen Reed 

PROVIDER: E-GEOD-70262 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress