Nucleosome Distribution Data for Methylphenidate Treatment

ABSTRACT: Jurkat T-leukemic cells at 0, 15, 45, and 240 minutes post MPH treatment. Chromatin structure depends highly on the position and density of nucleosomes in the genome. The distribution of these nucleosomes likely plays a critical role in all processes for which DNA is the template, including: gene expression, DNA replication, recombination and repair. It has been proposed for more than half a century that although all the cells in a human body contain, essentially, the same genetic material, nucleosomes give access to different areas of the genome effectively giving access to cell-type specific areas of the genome. We hypothesized that alterations in nucleosome distribution might play a role in the MPH stimulated immune response. We measured chromatin structural changes in a human T-cell l

ORGANISM(S): Homo sapiens

SUBMITTER: Jonathan Dennis 

PROVIDER: E-GEOD-70292 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress