Transcriptomic profiling of the inflammatory response after trauma

ABSTRACT: The study was aimed to identify mechanisms linked to complicated courses after severe trauma by a systems biology approach. In severe trauma, overwhelming systemic inflammation can result in adverse events and the development of complications, including sepsis. In a prospective study, RNA samples from circulating leukocytes from patients with multiple injury (injury severity score ≥ 17) were analyzed for dynamic changes in gene expression over a period of 21 days by whole genome screening. Based on their clinical presentation, patients were divided into two subgroups: patients with secondary sepsis after trauma (n=5) and patients with systemic inflammation without infection (n=5). Expression cluster were defined by correlating gene expression data with clinical outcome parameters. Using

ORGANISM(S): Homo sapiens

SUBMITTER: S. Lambeck 

PROVIDER: E-GEOD-70311 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress