Chronic psoriatic skin inflammation leads to increased monocyte adhesion and aggregation

ABSTRACT: Psoriasis patients exhibit an increased risk of death by cardiovascular disease (CVD) and have elevated levels of circulating intermediate (CD14++CD16+) monocytes. This elevation could represent evidence of monocyte dysfunction in psoriasis patients at risk of CVD, as increases in circulating CD14++CD16+ monocytes are predictive of myocardial infarction and death. An elevation in the CD14++CD16+ cell population has been previously reported in patients with psoriatic disease, which has been confirmed in the cohort of our human psoriasis patients. CD16 expression was induced in CD14++CD16neg classical monocytes following plastic adhesion, which also elicited enhanced β2 but not β1 integrin surface expression, suggesting increased adhesive capacity. Indeed, we found that psoriasis patients h

ORGANISM(S): Homo sapiens

SUBMITTER: Jackelyn Golden 

PROVIDER: E-GEOD-70327 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress