Patient Derived Xenograft for Delivery of Precision Medicine in Castrate Resistant Prostate Cancer

ABSTRACT: Developing animal models representating the cancer biology of advanced prostate cancer patients is challenging but essential for delivering individualized medical therapies. In an effort to develop patient derived xenograft (PDX) models, we took the metastatic site tissue from the rib lesion twice (ie, before and after enzalutamide treatment) over a twelve week period and implanted subcutaneously and under the renal capsule in immuno-deficient mice. To characterize and compare the genome and transcriptome landscapes of patient tumor tissues and the corresponding PDX models, we performed whole exome and transcriptome sequencing for metastatic tumor tissue as well as its derived PDXs. We demonstrated the feasibility of developping PDX models from patient who developed castrate-resistant pr

ORGANISM(S): Homo sapiens

SUBMITTER: Hugues Sicotte 

PROVIDER: E-GEOD-70380 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress