Binary cell fate decision as high-dimensional critical state transition

ABSTRACT: During commitment of a multipotent stem or progenitor cell to a particular lineage, a large number of genes alter their expression in a coordinated manner orchestrated by the gene regulatory network (GRN). The constraints imposed by the GRN govern how cells move in the high-dimensional gene expression state space and can be understood as a dynamical system in which phenotypic cell states (cell types) are attractors that stabilize the cell-type characteristic gene expression pattern against molecular noise. Despite insights from various theoretical models, it remains elusive how multipotent cells, when committing to a specific lineage, exit their attractor and enter a new distinct attractor. Here we show, using single-cell resolution monitoring of transcript patterns by qPCR that commitment

ORGANISM(S): Mus musculus

SUBMITTER: Mitra Mojtahedi 

PROVIDER: E-GEOD-70405 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress