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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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SMARCB1-deficient rhaboid tumors of the kidney and renal medullary carcinomas.

ABSTRACT: We used microarrays to compared gene expression profilings in various tumors of the kidney. [human mRNA] 8 human RTK, 5 human RMC.

ORGANISM(S): Homo sapiens

SUBMITTER: Wilfrid Richer

PROVIDER: E-GEOD-70421 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Balanced Translocations Disrupting SMARCB1 Are Hallmark Recurrent Genetic Alterations in Renal Medullary Carcinomas.

Calderaro Julien J Masliah-Planchon Julien J Richer Wilfrid W Maillot Laetitia L Maille Pascale P Mansuy Ludovic L Bastien Claire C de la Taille Alexandre A Boussion Hélène H Charpy Cécile C Jourdain Anne A Bléchet Claire C Pierron Gaelle G Gentien David D Choudat Laurence L Tournigand Christophe C Delattre Olivier O Allory Yves Y Bourdeaut Franck F

European urology 20151001 6

<h4>Background</h4>Renal medullary carcinoma (RMC) is a rare and highly aggressive neoplasm that most often occurs in the setting of sickle cell trait or sickle cell disease (SCD). Most patients present with metastatic disease resistant to conventional chemotherapy, and therefore there is an urgent need for molecular insight to propose new therapies.<h4>Objective</h4>To determine the molecular alterations and oncogenic pathways that drive RMC development.<h4>Design, setting, and participants</h4 ...[more]

PMID: 26433572

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