Loss of EZH2 results in precocious mammary gland development and the activation of STAT5-dependent genes

ABSTRACT: Establishment and differentiation of mammary alveoli during pregnancy are controlled by prolactin through the transcription factor STAT5. As pregnancy progresses mammary signature genes are activated in a defined temporal order, which coincides with the recruitment of STAT5 to respective regulatory sequences. This study addressed the question whether the methyltransferase and transcriptional co-activator EZH2 controls the differentiation clock of mammary epithelium. Ablation of Ezh2 from mammary stem cells resulted in precocious differentiation of alveolar epithelium during pregnancy and the activation of mammary-specific STAT5 target genes. This coincided with enhanced occupancy by STAT5, EZH1 and Pol II to these loci. Limited activation of differentiation-specific genes was also observed

ORGANISM(S): Mus musculus

SUBMITTER: Sumin Oh 

PROVIDER: E-GEOD-70440 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress