Stromal Fat4 acts non-autonomously with Dachsous1/2 to restrict the nephron progenitor pool

ABSTRACT: Regulation of the balance between progenitor self-renewal and differentiation is critical to development. In the mammalian kidney, reciprocal signaling between three lineages (stromal, mesenchymal and ureteric) ensures correct nephron progenitor self-renewal and differentiation. Loss of either the atypical cadherin Fat4 or its ligand Dachsous1 (Dchs1) results in expansion of the mesenchymal nephron progenitor pool, called the condensing mesenchyme (CM). This has been proposed to be due to misregulation of the Hippo kinase pathway transcriptional co-activator YAP. Here, we use tissue-specific deletions to prove that Fat4 acts non-autonomously in the renal stroma to control nephron progenitors. We show that loss of Yap from the CM in a Fat4-null background does not reduce the expanded CM, in

ORGANISM(S): Mus musculus

SUBMITTER: Qun Pan 

PROVIDER: E-GEOD-70452 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress