Integrating high-dimensional transcriptomics and image analysis tools into early safety screening (II)

ABSTRACT: In this paper we demonstrated the potential to flag toxicity issues by utilizing data from exploratory experiments which are typically generated for target evaluation purposes during early drug discovery During drug discovery and development, the early identification of adverse effects is expected to reduce costly late stage failures of candidate drugs. As risk/safety assessment takes place rather late during the development process and due to the limited predictivity of animal models to the human situation, modern unbiased high-dimensional biology read-outs are sought, such as molecular signatures of in vivo response using high-throughput cell-based assays. In this theoretical proof-of-concept we provide findings of an in-depth exploration of a single chemical core structure. Via transcri

ORGANISM(S): Homo sapiens

SUBMITTER: Steven Osselaer 

PROVIDER: E-GEOD-70613 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress