Gene expression profiling of Type II Enteropathy-associated T-cell lymphoma

ABSTRACT: Type II Enteropathy-associated T-cell lymphoma (Type II EATL) is an aggressive intestinal T-cell lymphoma with poor prognosis and has not been molecularly profiled. Through targeted amplicon sequencing, we identified a large portion of Type II EATL samples that harbor mutations in the STAT5B, JAK3 and GNAI2 genes. Here we performed gene expression profiling on four Type II EATL samples in order to better characterize this disease. As Type II EATL is suggested to arise from CD8+ IELs, we integrated our data with publicly available profile of CD8αα and CD8αβ T-cells from healthy donors (GSE33374). Gene expression profiling independently demonstrated strong enrichment of several aspects of GPCR and JAK-STAT signaling pathways. Moreover, an significant association was identified with genes

ORGANISM(S): Homo sapiens

SUBMITTER: Sanjanaa Nagarajan 

PROVIDER: E-GEOD-70652 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress