Gene expression in experimental aortic coarctation and repair: candidate genes for therapeutic intervention?

ABSTRACT: The objective of the current investigation was to use microarray techniques to quantify differentially expressed genes (DEGs) in the upstream aorta subjected to high arterial BP after surgical induction of CoA, and restoration of normal arterial BP after its correction. DEGs may offer additional insight into potential mechanisms of persistent CV morbidity despite successful surgical repair. Male New Zealand white rabbits ~10 weeks old and weighing ~1.0 kg randomly underwent proximal dAo CoA. A 20 mmHg BP gradient was imposed using silk (permanent) or Vicryl (degradable) suture to mimic untreated CoA and surgically corrected CoA, respectively. Rabbits develop a pronounced stenosis and accompanying elevated BP as a stimulus for arterial remodeling within one week. Degradation of Vicryl sutur

ORGANISM(S): Oryctolagus cuniculus

SUBMITTER: John LaDisa 

PROVIDER: E-GEOD-70687 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress