Characterization of the molecular signature associated with the ablation of integrin α6 in IECs in the α6ΔIEC-TAM mouse model

ABSTRACT: Transcriptome analysis of mRNAs extracted from the rectal mucosa of WT and α6ΔIEC-TAM mice, 15 days after tamoxifen treatment Inflammatory bowel diseases (IBD) in humans are characterized by chronic inflammation and gastrointestinal tissue damage, caused by a combination of genetic and environmental factors. We show that the specific ablation of integrin α6 in intestinal epithelial cells (IECs) results in spontaneous colorectal inflammation in mice. In order to characterize the earlier molecular signature involved in the onset of inflammation, we performed Affymetrix microarrays and compare control versus α6ΔIEC-TAM transcriptomes after tamoxifen treatment. RNAs were prepared from rectal mucosa of 3 control mice treated with tamoxifen, 4 mutant mice treated with tamoxifen and 4 muta

ORGANISM(S): Mus musculus

SUBMITTER: Doulaye Dembele 

PROVIDER: E-GEOD-70700 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress