The prognostic significance of the dynamic changes of miRNA expression in locally advanced BC during neo-adjuvant chemotherapy treatment

ABSTRACT: Introduction: MicroRNAs (miRNAs) are small non-coding RNA that play a vital role in cancer progression. Neo-adjuvant chemotherapy (NAC) has become the standard of care for locally advanced breast cancer. The aim of this study was to evaluate miRNA alterations during NAC using multiple samples of tissue and serum to correlate miRNA expression with clinico-pathological features and patient outcomes. Methods: Tissue and serum samples were collected from patients with locally advanced breast cancer undergoing NAC at four time points: time of diagnosis, after the first and fourth cycle of doxorubicin/cyclophosphamide treatment, and after the fourth cycle of docetaxel administration. First, we evaluated the miRNA expression profiles in tissue and correlated expression with clinico-pathological f

ORGANISM(S): Homo sapiens

SUBMITTER: Manal Al Khanbashi 

PROVIDER: E-GEOD-70754 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress