Transcription profiling of mouse liver to investigate the effect of CLA diet on liver gene expression

ABSTRACT: apoE-deficient mice were fed a Western-type diet enriched with linoleic acid (control), cis-9, trans-11-CLA or trans-10, cis-12-CLA (1.0 % wt/wt) for 12 weeks and their hepatic gene expression was analysed using DNA microarrays Experiment Overall Design: Three experimental designs using different genetic models as well as dietary conditions were carried out. In the first experiment, twenty nine three month-old homozygous apoE knockout male mice with a C57BL/6JxOLA129 genetic background, bred at the Unidad Mixta de Investigación, Zaragoza, were randomly assigned to a control (n=10), c9,t11-CLA-enriched (n=10) or t10,c12-CLA-enriched (n=9) diet. All mice had similar baseline plasma cholesterol concentrations. The mice were fed the different experimental semi-purified diets for 12 weeks. Al

ORGANISM(S): Mus musculus

SUBMITTER: Jesus Osada 

PROVIDER: E-GEOD-7076 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress