Comparative genomic hybridization of human osteosarcoma cell lines to identify microaberrations

ABSTRACT: Background: Osteosarcoma (OS) is a very aggressive bone tumor characterized by highly abnormal complex karyotypes. With the improved resolution offered by array comparative genomic hybridization (array CGH) platforms, it is possible to readily detect cryptic microaberrations in genomic DNA. The identification of these microaberrations in genetic syndromes is currently the focus of many array CGH studies, but there have been no analyses to date documenting the occurrence of microaberrations in tumors. Results: In this study we utilized high-resolution oligonucleotide array CGH to identify novel microaberrations under ~750 kb in four OS-derived cell lines: U-2 OS, HOS, MG-63 and SAOS-2. Comparative analysis of these alterations showed that SAOS-2 harbored the most microaberrations at 17

ORGANISM(S): Homo sapiens

SUBMITTER: Shamini Selvarajah 

PROVIDER: E-GEOD-7077 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress