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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MntR(Rv2788): a transcriptional regulator that controls manganese homeostasis in Mycobacterium tuberculosis.

ABSTRACT: Transcriptional profiling of SirR and manganese regulated expression of genes in Mycobacterium tuberculosis strains comparing high manganese vs. low manganese in Rv (wild type Mycobacterium tuberculosis) and ST70 (mntR mutant strain of Mycobacterium tuberculosis) Two strains each with two conditions experiment, Rv (Mycobacterium tuberculosis wild type strain) high manganese vs. low manganese and ST70 (mntR mutant strain of Mycobacterium tuberculosis) high manganese vs. low manganese. Number of biological replicates is 3 for each condition for each strain.

ORGANISM(S): Mycobacterium tuberculosis

SUBMITTER: G Rodriguez

PROVIDER: E-GEOD-70812 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MntR(Rv2788): a transcriptional regulator that controls manganese homeostasis in Mycobacterium tuberculosis.

Pandey Ruchi R Russo Riccardo R Ghanny Saleena S Huang Xiaojuan X Helmann John J Rodriguez G Marcela GM

Molecular microbiology 20151001 6

The pathogenic mycobacterium Mycobacterium tuberculosis encodes two members of the DtxR/MntR family of metalloregulators, IdeR and SirR. IdeR represses gene expression in response to ferrous iron, and we here demonstrate that SirR (Rv2788), although also annotated as an iron-dependent repressor, functions instead as a manganese-dependent transcriptional repressor and is therefore renamed MntR. MntR regulates transporters that promote manganese import and genes that respond to metal ion deficienc ...[more]

PMID: 26337157

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