Age and estrogen-dependent inflammation in breast adenocarcinoma and normal breast tissue [cohort_2]

ABSTRACT: Chronic inflammation promotes breast tumor growth and invasion by accelerating angiogenesis and tissue remodeling in the tumor microenvironment. The relationship between inflammation and estrogen, which drives the growth of 70 percent of breast tumors, is complex. Low levels of estrogen exposure stimulate macrophages and other inflammatory cell populations, but very high levels are immune suppressive. Breast tumor incidence is increased by obesity and age, which interact to influence inflammatory cell populations in normal breast tissue. The molecular impact of these factors on tumor initiation and growth is not well-understood. We modeled the difference in gene expression between 195 breast adenocarcinomas and 195 matched adjacent normal breast tissue samples, using age, body mass index

ORGANISM(S): Homo sapiens

SUBMITTER: David Quigley 

PROVIDER: E-GEOD-70947 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress