Antitumor Activity of the Novel Flavonoid Oncamex in Preclinical Breast Cancer Models

ABSTRACT: Introduction: The flavonoid myricetin has been shown to induce cell cycle arrest and mitochondrial-dependent apoptosis in preclinical cancer models. We hypothesised that myricetin-derived flavonoids with redox properties and improved physicochemical attributes that enhance cell uptake and mitochondrial targeting might have increased potential as antitumour agents, since mitochondria are the main site of production of reactive oxygen species (ROS) and redox status is known to regulate the development and advancement of certain cancers. In this study we assessed a small library of novel flavonoids, then focussed on the lead compound, second-generation analogue OncamexTM, its mechanism of action and structure-activity relationships as an anti-proliferative agent. Methods: With this aim, we st

ORGANISM(S): Homo sapiens

SUBMITTER: Carlos Martinez-Perez 

PROVIDER: E-GEOD-70949 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress