Blimp1 controls plasma cell physiology and function

ABSTRACT: Antibody-secreting plasma cells are the terminal stage of the B-cell lineage. Plasma cell differentiation requires a major resetting of gene expression to silence the B cell transcriptional program, whilst establishing secretory function and long-term survival. The transcription factors Blimp1 and Irf4 are essential for the initial differentiation of activated B cells to antibody-secreting cells, however their function in mature plasma cells remains elusive. We have found that while Irf4 was essential for plasma cell survival, Blimp1 was dispensable. Blimp1-deficient cells retained the unique plasma cell transcriptional signature, but lost the ability to secrete antibody or to maintain the characteristic size and ultrastructure of plasma cells. Blimp1 was required for full expression of ma

ORGANISM(S): Mus musculus

SUBMITTER: Wei Shi 

PROVIDER: E-GEOD-70981 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress