Genomic and transcriptomic analysis of the streptomycin-dependent Mycobacterium tuberculosis 18b

ABSTRACT: Introduction: Tuberculosis (TB) is a serious human disease caused by the bacterium Mycobacterium tuberculosis (Mtb). One third of the world’s population is estimated to be latently infected with Mtb. Exact mechanisms and properties of latent TB infection (LTBI) are not fully elucidated. In essence, the pathogen can enter a dormant or latent state characterized by limited growth and metabolism, resulting in absence of clinical symptoms in the host, and most importantly by increased phenotypic tolerance to the commonly used medications, thereby allowing indefinite persistence in the human body. This persistence is the main reason why the current treatment of new-onset pulmonary TB is very long, consisting of a six months therapy of four antibiotics (rifampicin, isoniazid, pyrazinamide, and

ORGANISM(S): Mycobacterium tuberculosis

SUBMITTER: Andrej Benjak 

PROVIDER: E-GEOD-71066 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress