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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from isogenic Pten WT mouse T-ALLs infected with MSCV Myr-AKT-IRES-mCherry or empty vector, treated with DBZ or DMSO

ABSTRACT: To explore the mechanisms downstream of NOTCH1 and PTEN in the control of leukemia cell growth, we performed expression profiling on NOTCH1 induced and Pten-positive T-ALL tumor cells infected with constitutively active AKT (myristoylated-AKT). Constitutive activation of AKT rescues the transcriptional programs induced by NOTCH1 inhibition in Pten-positive T-ALL cells We performed microarray gene expression analysis of GSI treatment in Pten WT NOTCH1 induced leukemias infected with constitutively active AKT (myristoylated-AKT) or empty vector.

ORGANISM(S): Mus musculus

SUBMITTER: Alberto Ambesi-Impiombato

PROVIDER: E-GEOD-71089 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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