A fraction of steady state splenic XCR1+ dendritic cells undergo an homeostatic maturation as assessed by their upregulation of CCR7 or of IL-12, and by their profound genetic reprogramming

ABSTRACT: XCR1+ dendritic cells (DC) have been shown to excel in antigen cross-presentation for the activation of naïve CD8 T cells. This property was reported to be associated to the subset of the XCR1+ DC expressing IL-12b upon ex vivo stimulation for 24 h with a mixture of CpG, IFN-γ, and GM-CSF (Lin ML et al. Proc Natl Acad Sci USA. 2008. PMID: 18272486). DC found in the steady-state non-lymphoid tissues undergo an homeostatic, tolerogenic, maturation and migrate to the draining lymph nodes to interact with naive autoreactive T cells and induction their peripheral tolerance. In contrast, spleen DC are thought to exist solely in an immature state. The aim of this study was to re-examine heterogeneity within steady state spleen XCR1+ DC, in particular examining whether this population encompass

ORGANISM(S): Mus musculus

SUBMITTER: Marc DALOD 

PROVIDER: E-GEOD-71167 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress